Catecholamine assay kit

Test indicators:epinephrine, norepinephrine, dopamine, 3- methoxytyramine,methoxyepinephrine, methoxynorepinephrine

Sample requirements: plasma

Intended use:for the detection of catecholamine and its metabolites levels in vivo

Catecholamine and Pheochromocytoma

Catecholamine is an important neurotransmitter in the body, and includes dopamine (DA), norepinephrine (NE), epinephrine (E), and derivatives of methoxyepinephrine (MN), methoxynorepinephrine (NMN), and 3- methoxytyramine (3-MT). They are closely related to a variety of physiological and pathological phenomena and play a key role in the body’s maintenance of endostatic homeostasis. Catecholamines are specific markers for pheochromocytoma and paraganglioma (PPGLs) and can be used clinically to assist in the diagnosis of endocrine-related diseases such as hypertension, hyperthyroidism, pheochromocytoma, and neuroblastoma.

The prevalence of pheochromocytoma in hypertensive patients is 0.05%–0.2%, with a peak incidence between 20–50 years of age. Pheochromocytoma is found in the adrenal gland in 80%–90% of cases; the clinical manifestations of this disease vary widely among individuals, with sudden onset of malignant hypertension, heart failure, cerebral hemorrhage, etc. Clinical symptoms and signs are related to excessive catecholamine secretion, manifesting as hypertension, headache, palpitation, hypermetabolic state, hyperglycemia, and excessive sweating.

Indicated for:

• Patients with paroxysmal hypertension who also suffer from headache, palpitation, and excessive sweating.

• Patients with intractable hypertension.

• People with a family history of PPGLs or related genetic syndromes.

• People with a previous history of PPGLs.

• PPGL post-operative patients.